Thank you for joining us this evening for some thrilling La Liga action.
We will be back tomorrow for Barcelona v Real Sociedad, kicking off at 15.15 GMT. Hopefully we will see you then.
The 32-year-old scored 53 goals in 353 games for Real Madrid, winning the Champions League five times and La Liga three times in nine years at the club.
Tonight he rolled back the years with a dominant showing, assisting one goal and scoring the other. He also had 97 touches in midfield – the most of any Betis player, and the only man who had more was Luka Modric.
Isco’s penalty was his sixth goal in 15 games this season – with four of them coming in the past month.
Betis ended this game with 18 shots to Real Madrid’s nine. After a slow start they outplayed their opponents.
It is the first time in 10 meetings with Madrid that Betis manager Manuel Pellegrini has guided his team to victory over Los Blancos.
Well, Real Madrid need to pick themselves up sharpish – in around 72 hours they will face Atletico Madrid in the first leg of their Champions League round of 16 tie.
A saving grace for the European champions is that Jude Bellingham, suspended tonight, will be available for that game.
A blow for Real Madrid in the La Liga title race. They could be third by the end of the weekend.
Betis meanwhile move into the top six.
BBC Sport
Vinicius Jr threw a bit of a tantrum as the game slipped away, and is making a sharp exit from the field.
The Betis players soak up the adulation of their fans, and rightly so. They deserve this victory.
A huge win!
Lucas Vazquez has a shot blocked, then Arda Guler fouls Diego Llorente.
Adrian has not had a lot to do tonight, but the Betis keeper shows authority to come and punch away a deep cross.
Madrid president Florentino Perez is in the stands tonight.
One can only imagine he is thoroughly unimpressed by what he has witnessed here.
Real Betis only have to see out four minutes of injury time to seal a famous win.
Endrick badly skews a Madrid shot wide.
Final Betis change, and Manuel Pellegrini is sending on another centre back.
Natan replaces midfielder Sergi Altimira.
Vinicius bursts into the Betis area, but is denied by another excellent Marc Bartra tackle.
There is then a set-to over the ball, as Vinicius tries to rip it away from Bartra. He is at risk of losing his head, the Madrid forward.
Vinicius Jr is very agitated, and has talked himself into a yellow card.
Frustration all around for Madrid tonight.
Fran Garcia replaces Ferland Mendy, a like for like change at left back for Madrid.
Vinicius with a strike from distance, straight at former Liverpool keeper Adrian.
Chimy Avila is also in the book for Betis.
Real Madrid are starting to push the home side back now.
Real Madrid need Bellingham. He is the engine that keeps all the other parts moving. He has been sorely missed tonight for Madrid.
Mike, East Yorkshire
Into the final 10 mins.
Betis captain Isco is booked for a foul on Lucas Vazquez.
Double change for the hosts – Cedric Bakambu replaces Cucho, and Aitor Ruibal comes on for Youssouf Sabaly.
Getty Images
Emlyn Begley
BBC Sport journalist
Real Betis came from behind to beat Real Madrid with Isco scoring the winner against his former club.
The visitors, who sit second in La Liga, went ahead when Kylian Mbappe picked out Ferland Mendy, who squared for Brahim Diaz to slot into an empty net from close range.
Madrid had a couple of chances to double their lead before Johnny Cardoso equalised with a 34th-minute header from Isco’s corner.
Isco – captaining Betis against the club where he spent nine years – then netted a 54th-minute penalty after Antonio Rudiger had fouled Jesus Rodriguez in the box.
The hosts almost got a third when Cucho Hernandez shot wide after being picked out by Manchester United loanee Antony, who was available after his side won an appeal against his red card last week.
Betis, managed by ex-Madrid and Manchester City boss Manuel Pellegrini, move up to sixth in the La Liga table and fully deserved their victory with 18 shots to Madrid’s nine.
It was the fourth time this season Carlo Ancelotti’s side have lost in La Liga and they remain behind Barcelona on goal difference.
Atletico Madrid could overtake them with a win against Athletic Bilbao later on Saturday (20:00 GMT).
Isco enjoys facing old side
Reuters
Isco scored 53 goals in 353 games for Real Madrid, winning the Champions League five times and La Liga three times in nine years at the club.
The 32-year-old former Spain attacking midfielder joined Betis in 2023 after a short spell at neighbours Sevilla.
As well as assisting one goal and scoring the other, he ran the show with 97 touches, only behind former team-mate Luka Modric.
He picked up a late yellow card for time wasting.
This was his sixth goal in 15 games this season – with four of them coming in the past month.
